Monday, August 20, 2012
Premature Rupture of Membranes (PROM) and
Preterm Premature Rupture of Membranes (pPROM)
Premature rupture of membranes (PROM) refers
to a woman who is beyond 37 weeks' gestation and has presented with rupture of
membranes prior to the onset of labor. Rupture of membranes is more commonly
referred to as “water broke” or “broken sac”. Preterm premature rupture of membranes pPPROM) is a repture
of membranes prior to 37 weeks' gestation. pPROM
is associated with 30-40% of preterm deliveries and is the leading identifiable
cause of preterm delivery. pPROM
complicates 3% of all pregnancies and occurs in approximately 150,000
pregnancies yearly in the United States.[1][2]
Causes
pPROM is a bit more difficult to pinpoint causes, however it is likely due to the same mechanisms and premature activation of these pathways. However, pPROM appears to be linked to underlying pathologic processes as well, most likely due to inflammation and/or infection of the membranes. Clinical factors associated with pPROM include low socioeconomic status, low body mass index, tobacco use, preterm labor history, urinary tract infection, vaginal bleeding at any time in pregnancy, cerclage, and amniocentesis. [3]
I was laying in bed while I was 25 weeks
pregnant with boy/girl twins, watching the evening news, when I felt wet “down
there”. I literally started
giggling as I thought to myself, “I’m only 25 weeks pregnant and I’m already
peeing my pants!” I got out of
bed, took my yoga pants off, and noticed it was a little more than the dribble
I felt. I walked to the bathroom
where I sat on the toilet, stood up, and a huge WOOSH of water came out. I knew right then and there that it
wasn’t urine, it was fluid, and that my water had broke. I called my OB and she told me to put a
pad on and get to the hospital. I
told them that at this point we were beyond a pad, hung up the phone, stuck a
towel between my legs, and headed to the hospital where they confirmed almost
immediately via an AmnioSense strip test that it was amniotic fluid. Looking back, I believe bleeding from a
subchorionic hemorrhage or hematoma present with
Baby A from weeks 9 until 17 deteriorated her sac and caused my pPROM.
Treatment and Risks
Unfortunately, there is no
treatment for PROM or pPROM. With
PROM doctors feel that, in the majority of cases, it is safer for both the
mother and baby to induce labor and deliver early. However, some doctors may choose to put a mother on hospital
bedrest and a non-stress test (NST) given daily to monitor the baby and ensure
there is no distress. Antibiotics
are likely to be administered to ward off infection. There remain different schools of thought, but PROM mothers
are likely to face immediate delivery.
The course of action for pPROM is significantly
different. Mothers are put on strict
hospital bed rest with constant monitoring unless there are other significant
risks to the mother and / or baby to consider including fetal distress. In those cases, immediate delivery is
suggested. The hope is to stop /
prevent labor and stave off infection for as long as possible with the goal to keep
the baby in for as long as possible until it is safer outside than inside. Since amniotic fluid is essentially
baby urine, a baby can last quite some time in a broken sac as long as
infection stays away. Magnesium sulfate is often given to stop labor and corticosteroid shots (ex. betamethasone) to help accelerate the development of the baby’s lungs. Magnesium sulfate is also linked to protecting the sensitive tissues of the brain in premature babies and can lessen the risk of cerebral palsy. An antibiotic regimen is also started to work against any potential infection and NSTs are conducted at least daily. Additional monitoring such as ultrasounds to identify size and monitor fluid levels may be prescribed as well.
An ultrasound was conducted that showed
Baby A, baby girl Keltie, had a broken sac and low amniotic fluid. Baby B, baby boy Colton, had a sac
still intact and both babies were not in distress. While in the admitting room, they also found I was
contracting every 3-4 minutes and I was immediately given a steroid shot (the
first in a series of two) and started on magnesium sulfate to stop the
labor. I was put on strict bed
rest where I couldn’t get up to use the bathroom or shower. But, I was willing to do anything to
keep the babies inside for as long as possible. I had three goals given to me: 1 – make it 24 hours for the second steroid shot, 2 – make
it another 24 hours past that to have the steroid series considered “complete”,
and 3 – make it to 26 weeks gestation where the survivability rate goes from
50% to 75% for the babies.
The vast majority of women proceed to go into
active labor and deliver soon after pPROM. With appropriate therapy and
conservative management, approximately 50% of all remaining pregnancies deliver
within one week after pPROM. Thus, very few women remain pregnant more than 3-4
weeks after pPROM. Spontaneous
sealing of the membranes does occur occasionally (< 10% of all cases),
mostly after pPROM that has occurred subsequent to amniocentesis; however, this
is the exception rather than the rule. [4] Women suffering pPROM should ensure
they are at a hospital with a Level III NICU capable of dealing with babies
less than 34 weeks gestation. If
not, a transfer request should be made to one able to handle complicated
premature babies.
I made it 4 days before Keltie stuck her
feet through my cervix and sent me into full blown labor. I was rushed in for an emergency
c-section and on January 24, 2012 at 3:19am at only 26 weeks and 1 day
gestation, I gave birth to two beautiful twins. Colton weighed 1lb, 13oz and Keltie weighed 1lb, 9oz and
both were 13 inches long. After
100 days in the NICU, Keltie joined us at home. Six weeks later and after 142 days in the NICU, her brother
Colton finally joined us – that was the happy ending we were waiting for. Today they are growing and thriving –
to learn more about our story, please visit: Project26WeekPreemies.
[1] http://emedicine.medscape.com/article/261137-overview#a1
[2] http://www.tommys.org/page.aspx?pid=972
[3] http://emedicine.medscape.com/article/261137-overview#a1
[4] http://emedicine.medscape.com/article/261137-overview#a1
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3 comments:
I had pProm when I was 34 weeks. Wonder how doctors will handle my next pregnancy?
Loved reading this, Krista. You wrote it so well. xo Christine
You guys present there are performing an excellent job.Go to Rik Lei
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